Recurrent Corneal Erosion

Recurrent corneal erosion (RCE) is a chronic relapsing condition caused by the corneal epithelium breaking down and loosening. Patients also experience sudden onsets of pain, tearing, and light sensitivity. RCE is typically caused by trauma to the eye or other preexisting corneal dystrophies. Patients with higher risk of developing RCE include those with diabetes or dry eye syndrome. There are both medical and surgical treatments for RCE, including lubricants, antibiotics, corticoesteroids, bandage contact lens placement, punctal occulsion, micropuncture, PTK, diamond burr polishing, and the increasingly popular amniotic membrane tissue graft.

Central recurrent corneal erosion. Photo: Shaun Coombs, OD

Atlas Amniotic Membrane to Treat RCE

Amniotic membrane is a natural tissue derived from the innermost layers of the placenta, donated by women after giving birth. It has been used for various wound healing applications across the body, including the ocular surface. Over the past decade, there has been an increasing amount of support for the use of amniotic membrane to treat RCE.

Tissue grafts of amniotic membrane have been shown to reduce inflammation and scarring, while also promoting reepithelialization and healing processes. A very thin disc of sterile tissue (about the width of a dime) is placed on the eye and is covered by a regular bandage contact lens. Over the next 5-7 days, the tissue is absorbed by the eye and aids in the healing process. Both ophthalmologists and optometrists can place the amniotic membrane graft quickly and easily right in the exam room.

Use of amniotic membrane grafts for the treatment of RCE are typically covered by insurance*. Further, articles supporting the use of amniotic membrane for RCE can be found in Review of Ophthalmology, Review of Optometry, Healio, Optometry Times,, California Optometric Association (case study), and more.
*As all insurance plans are different, please consult with your insurance company directly to determine if you have coverage

Features & Specifications

  • Disc Sizes: 10mm, 12mm, 15mm
  • Sheet Sizes: 1x1cm, 2x2cm, 2x3cm
  • Thickness Options: 45 and 200 microns
  • Omni-directional placement. Membrane can be placed either-side down
  • 5-year shelf life at room temperature (50-86°F/10-30°C)
  • Easy to place and manipulate due to increased surface memory
  • More comfortable for patients
  • Membranes packaged in sterile dual-pouch and may be introduced into the sterile field

Indications for Use

  • Recurrent Corneal Erosion
  • Corneal Abrasion
  • Foreign Body Removal
  • Filamentary and Post-infectious Keratitis
  • Corneal Ulcers
  • Chemical and Thermal Burns
  • Superficial Keratectomy
  • PRK Haze
  • Neurotrophic Corneal Epithelial Defects
  • Dry Eye and Exposure Keratopathy
  • Salzmann’s Nodular Degeneration
  • Shield Ulcers
  • And More

Safety Information

Processed in accordance with the safety guidelines provided by the U.S. Food and Drug Administration (FDA) for Human Cellular and Tissue-based Products (HCT/P).

Processed in accordance with the standards set forth by the American Association of Tissue Banks (AATB).

Store tissue at ambient room temperature (50-86°F/10-30°C). Do not freeze.

Place Order / Request Quote

We will email a quote and verify your order by phone before fulfilling any online orders. We will also collect billing info at that time.

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